Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics
PL Collins, SS Whitehead, A Bukreyev, R Fearns… - Advances in virus …, 1999 - Elsevier
Publisher Summary This chapter describes the use of reverse genetics to prepare and
characterize live-attenuated recombinant versions of the respiratory syncytial virus (RSV) A2
strain (antigenic subgroup A).“Reverse genetics” is the reconstitution of biological
components from complementary DNA (cDNA). It is now possible to produce infectious
recombinant (r) RSV entirely from cDNA. Thus, predetermined changes can be introduced
into RSV through the cDNA intermediate. This provides a powerful tool for the studies of …
characterize live-attenuated recombinant versions of the respiratory syncytial virus (RSV) A2
strain (antigenic subgroup A).“Reverse genetics” is the reconstitution of biological
components from complementary DNA (cDNA). It is now possible to produce infectious
recombinant (r) RSV entirely from cDNA. Thus, predetermined changes can be introduced
into RSV through the cDNA intermediate. This provides a powerful tool for the studies of …
