Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections
RL Tominack, FG Hayden - Infectious disease clinics of North America, 1987 - Elsevier
Influenza viruses cause almost yearly epidemic outbreaks of acute febrile respiratory illness
throughout the world. Antigenic variation in the hemagglutinin (H) and neuraminidase (N)
surface glycoproteins of influenza A and B viruses accounts for their continued, cyclic
assault on human populations. The clinical course is self-limited in most patients, although
disabling constitutional symptoms at the onset and a 1-to 3-week convalescence often
ensue. Epidemiologic studies during influenza epidemics have estimated annual ill-ness …
throughout the world. Antigenic variation in the hemagglutinin (H) and neuraminidase (N)
surface glycoproteins of influenza A and B viruses accounts for their continued, cyclic
assault on human populations. The clinical course is self-limited in most patients, although
disabling constitutional symptoms at the onset and a 1-to 3-week convalescence often
ensue. Epidemiologic studies during influenza epidemics have estimated annual ill-ness …
