[HTML][HTML] β-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent …
Cardiac hypertrophy often leads to heart failure and is associated with abnormal myocardial
adrenergic signaling. This enlargement of myocardial mass can involve not only an increase
in cardiomyocyte size, but increased proliferation of cardiac fibroblasts. A potential key
player in the cardiac hypertrophic response is the ERK family of MAPKs. To gain
mechanistic insight into adrenergic regulation of myocardial mitogenic signaling, we
examined β-adrenergic receptor (β-AR) stimulation of ERK activation and DNA synthesis in …
adrenergic signaling. This enlargement of myocardial mass can involve not only an increase
in cardiomyocyte size, but increased proliferation of cardiac fibroblasts. A potential key
player in the cardiac hypertrophic response is the ERK family of MAPKs. To gain
mechanistic insight into adrenergic regulation of myocardial mitogenic signaling, we
examined β-adrenergic receptor (β-AR) stimulation of ERK activation and DNA synthesis in …
