Severe pulmonary hypersensitivity associated with passive transfusion of a neutrophil-specific antibody
R Yomtovian, C Press, H Engman, W Kline, M Clay… - The Lancet, 1984 - Elsevier
R Yomtovian, C Press, H Engman, W Kline, M Clay, D Hammerschmidt, J McCullough
The Lancet, 1984•ElsevierA life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia
and transient hypocomplementaemia developed in a 73-year-old man after repair of an
abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by
granulocyte immunofluorescence and microagglutination in one of the transfused donor
units. In addition, activated complement component C5a was generated in vitro by
incubation of the patient's serum with the aortic graft material. This severe clinical reaction …
and transient hypocomplementaemia developed in a 73-year-old man after repair of an
abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by
granulocyte immunofluorescence and microagglutination in one of the transfused donor
units. In addition, activated complement component C5a was generated in vitro by
incubation of the patient's serum with the aortic graft material. This severe clinical reaction …
Abstract
A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.
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