Thiazolidinedione associated volume overload and pulmonary hypertension

J Michaelson - Therapeutic Advances in Cardiovascular …, 2008 - journals.sagepub.com
J Michaelson
Therapeutic Advances in Cardiovascular Disease, 2008journals.sagepub.com
Thiazolidinediones are currently indicated for the treatment of Type 2 Diabetes. This class of
drugs has been associated with several adverse reactions associated with volume overload.
This report describes a case of a 65 year old African—American female with a history of
hypertension and obesity, and taking rosiglitazone (Avandia) for her Type 2 Diabetes whose
evaluation for chest pain resulted in the incidental finding of pulmonary hypertension noted
on echocardiogram. The subsequent evaluation, follow-up and treatment are discussed …
Thiazolidinediones are currently indicated for the treatment of Type 2 Diabetes. This class of drugs has been associated with several adverse reactions associated with volume overload. This report describes a case of a 65 year old African—American female with a history of hypertension and obesity, and taking rosiglitazone (Avandia) for her Type 2 Diabetes whose evaluation for chest pain resulted in the incidental finding of pulmonary hypertension noted on echocardiogram. The subsequent evaluation, follow-up and treatment are discussed along with potential pitfalls and implications for clinical care.
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