Adult-derived hippocampal progenitors generate neurons, astrocytes, and
oligodendrocytesin vitroand following grafting into the adult brain. Although these
progenitors have a considerable capacity forin vitroself renewal, it is not known if each
lineage is generated by separate committed precursors or by multipotent stem cells. By
genetic marking, we have followed individual cells through the process of proliferative
expansion, commitment, and differentiation. All three lineages are generated by single …