[HTML][HTML] Metabolic labeling reveals proteome dynamics of mouse mitochondria
Mitochondrial dysfunction is associated with many human diseases. Mitochondrial damage
is exacerbated by inadequate protein quality control and often further contributes to
pathogenesis. The maintenance of mitochondrial functions requires a delicate balance of
continuous protein synthesis and degradation, ie protein turnover. To understand
mitochondrial protein dynamics in vivo, we designed a metabolic heavy water (2 H 2 O)
labeling strategy customized to examine individual protein turnover in the mitochondria in a …
is exacerbated by inadequate protein quality control and often further contributes to
pathogenesis. The maintenance of mitochondrial functions requires a delicate balance of
continuous protein synthesis and degradation, ie protein turnover. To understand
mitochondrial protein dynamics in vivo, we designed a metabolic heavy water (2 H 2 O)
labeling strategy customized to examine individual protein turnover in the mitochondria in a …