Induction of IL-10+ CD4+ CD25+ T cells by grass pollen immunotherapy
Background: Immunotherapy involves the modulation of allergen-specific T-cell responses,
either TH2-to-TH1 immune deviation or, in bee venom-treated patients, induction of IL-10
production by CD4+ CD25+ T cells. IL-10-producing CD4+ CD25+ regulatory T cells have
emerged as potential mediators of immune tolerance in numerous murine models of
immunopathology. Objective: The aim of this study was to evaluate the role of IL-10
production and CD4+ CD25+ T cells in the response to grass pollen immunotherapy …
either TH2-to-TH1 immune deviation or, in bee venom-treated patients, induction of IL-10
production by CD4+ CD25+ T cells. IL-10-producing CD4+ CD25+ regulatory T cells have
emerged as potential mediators of immune tolerance in numerous murine models of
immunopathology. Objective: The aim of this study was to evaluate the role of IL-10
production and CD4+ CD25+ T cells in the response to grass pollen immunotherapy …