[CITATION][C] Regulatory mechanisms for the expression and activity of platelet-derived growth factor receptor.
K Funa, H Uramoto - Acta Biochimica Polonica, 2003 - ojs.ptbioch.edu.pl
PDGF is one of the most potent serum mitogens, and the signalling mechanism by way of its
receptor tyrosine-kinase has been extensively studied since its first purification in 1979. The
identification of homology between the simian sarcoma virus oncogene, v-sis, and the B-
chain of PDGF, as well as the frequent over-expression of both the ligands and receptors in
various tumours and stroma led to the proposal of the PDGF-mediated autocrine and
paracrine hypothesis. Consistent with the important roles of PDGF in the growth and survival …
receptor tyrosine-kinase has been extensively studied since its first purification in 1979. The
identification of homology between the simian sarcoma virus oncogene, v-sis, and the B-
chain of PDGF, as well as the frequent over-expression of both the ligands and receptors in
various tumours and stroma led to the proposal of the PDGF-mediated autocrine and
paracrine hypothesis. Consistent with the important roles of PDGF in the growth and survival …