Angiopoietin‐2: a multifaceted cytokine that functions in both angiogenesis and inflammation
Angiogenesis and inflammation are two highly linked processes. In the last decade, several
factors with dual function in both of these major pathways have been identified. This review
focuses on angiopoietin‐2 (Ang‐2), an important proangiogenic factor that has more
recently been implicated in mediating inflammatory processes as well. Ang‐2 is upregulated
in multiple inflammatory diseases and has been implicated in the direct control of
inflammation‐related signaling pathways. As a consequence of its multiple roles, designs for …
factors with dual function in both of these major pathways have been identified. This review
focuses on angiopoietin‐2 (Ang‐2), an important proangiogenic factor that has more
recently been implicated in mediating inflammatory processes as well. Ang‐2 is upregulated
in multiple inflammatory diseases and has been implicated in the direct control of
inflammation‐related signaling pathways. As a consequence of its multiple roles, designs for …
Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin‐2 (Ang‐2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang‐2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation‐related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang‐2 should consider the dual function of this factor in regulating angiogenesis and inflammation.
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