Serum hyaluronan—a potential marker of cardiac allograft rejection?
C Johnsson, G Tufveson - The Journal of heart and lung transplantation, 2006 - Elsevier
BACKGROUND: The connective tissue component hyaluronan accumulates within the
transplanted organ at rejection. Increased tissue content of hyaluronan is seen also in
synovial tissue in rheumatoid arthritis and in skin in scleroderma. In these diseases, the
elevated hyaluronan levels are reflected by increased concentrations of hyaluronan in
serum. The aim of the present study was to study the changes in serum hyaluronan after
organ transplantation. METHODS: The experiments were performed in a rat model of …
transplanted organ at rejection. Increased tissue content of hyaluronan is seen also in
synovial tissue in rheumatoid arthritis and in skin in scleroderma. In these diseases, the
elevated hyaluronan levels are reflected by increased concentrations of hyaluronan in
serum. The aim of the present study was to study the changes in serum hyaluronan after
organ transplantation. METHODS: The experiments were performed in a rat model of …