Postinjury inflammation and organ dysfunction
As advances in prehospital and acute hospital care conquered the so-called golden hour,
multiple organ failure (MOF) emerged as the leading cause of late trauma death. 1–3
Eiseman and colleagues 4 coined the term MOF in 1977, with a clinical description of 42
patients with progressive organ dysfunction (OD). By the 1990s, Moore and colleagues 5
Disclosures: Drs A. Sauaia and EE Moore received funding from the National Institute of
General Medical Sciences grant P50 GM049222 and the National Heart, Lung, and Blood …
multiple organ failure (MOF) emerged as the leading cause of late trauma death. 1–3
Eiseman and colleagues 4 coined the term MOF in 1977, with a clinical description of 42
patients with progressive organ dysfunction (OD). By the 1990s, Moore and colleagues 5
Disclosures: Drs A. Sauaia and EE Moore received funding from the National Institute of
General Medical Sciences grant P50 GM049222 and the National Heart, Lung, and Blood …
