A rapid increase in the synthesis of lipid-derived second messengers with subsequent
activation of protein phosphorylation cascades has emerged as one of the fundamental
mechanisms of signal transduction in animal cells. A plethora of external signals, including
hormones, neurotransmitters, growth factors, cytokines, bioactive lipids, and tastants
promote the stimulation of the isoforms of the PLC1 family, including,,, and. PLCs catalyze
the hydrolysis of phosphatidylinositol 4, 5-bisphosphate to produce two second messengers …