[HTML][HTML] A dynamic role for HDAC7 in MEF2-mediated muscle differentiation
The overlapping expression profile of MEF2 and the class-II histone deacetylase, HDAC7,
led us to investigate the functional interaction and relationship between these regulatory
proteins. HDAC7 expression inhibits the activity of MEF2 (-A,-C, and-D), and in contrast
MyoD and Myogenin activities are not affected. Glutathione S-transferase pulldown and
immunoprecipitation demonstrate that the repression mechanism involves direct interactions
between MEF2 proteins and HDAC7 and is associated with the ability of MEF2 to interact …
led us to investigate the functional interaction and relationship between these regulatory
proteins. HDAC7 expression inhibits the activity of MEF2 (-A,-C, and-D), and in contrast
MyoD and Myogenin activities are not affected. Glutathione S-transferase pulldown and
immunoprecipitation demonstrate that the repression mechanism involves direct interactions
between MEF2 proteins and HDAC7 and is associated with the ability of MEF2 to interact …