[HTML][HTML] Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation
M Busch, N White, L Shum, RA Eliseev - Journal of Biological Chemistry, 2018 - ASBMB
Bone marrow stromal (aka mesenchymal stem) cells (BMSCs) can differentiate into
osteoblasts (OBs), adipocytes, or chondrocytes. As BMSCs undergo OB differentiation, they
up-regulate mitochondrial oxidative phosphorylation (OxPhos). Here, we investigated the
mechanism (s) connecting mitochondrial OxPhos to OB differentiation. First, we found that
treating BMSC-like C3H10T1/2 cells with an OxPhos inhibitor reduces their osteogenic
potential. Interestingly, ATP levels were not reduced, as glycolysis compensated for the …
osteoblasts (OBs), adipocytes, or chondrocytes. As BMSCs undergo OB differentiation, they
up-regulate mitochondrial oxidative phosphorylation (OxPhos). Here, we investigated the
mechanism (s) connecting mitochondrial OxPhos to OB differentiation. First, we found that
treating BMSC-like C3H10T1/2 cells with an OxPhos inhibitor reduces their osteogenic
potential. Interestingly, ATP levels were not reduced, as glycolysis compensated for the …
