[HTML][HTML] Mammalian HSP60 is a major target for an immunosuppressant mizoribine
H Itoh, A Komatsuda, H Wakui, AB Miura… - Journal of Biological …, 1999 - ASBMB
It has been reported that immunosuppressant cyclosporin A or FK506 binds to
immunophilins in the cell and that these immunophilins make a complex with molecular
chaperones HSP70 or HSP90. Although mizoribine has been used clinically as an
immunosuppressant, immunophilins of the agent have not yet been fully understood. We
investigated their specific binding proteins using mizoribine affinity column chromatography
and porcine kidney cytosols. By increasing mizoribine in the eluant from the column, two …
immunophilins in the cell and that these immunophilins make a complex with molecular
chaperones HSP70 or HSP90. Although mizoribine has been used clinically as an
immunosuppressant, immunophilins of the agent have not yet been fully understood. We
investigated their specific binding proteins using mizoribine affinity column chromatography
and porcine kidney cytosols. By increasing mizoribine in the eluant from the column, two …
