[HTML][HTML] Contribution of chemokine CCL2/CCR2 signaling in the dorsal root ganglion and spinal cord to the maintenance of neuropathic pain in a rat model of lumbar …
X Zhu, S Cao, MD Zhu, JQ Liu, JJ Chen, YJ Gao - The journal of pain, 2014 - Elsevier
Lumbar disc herniation (LDH) is a major cause of sciatica, but the underlying mechanisms
are not well understood. Chemokine CCL2 has been implicated to play a vital role in the
neuroinflammation and central sensitization after spinal nerve ligation. Here we investigated
the expression and the role of CCL2 and its receptor CCR2 in LDH-induced pain.
Implantation of autologous nucleus pulposus induced persistent pain hypersensitivity,
associated with increased mRNA expression of CCL2 and CCR2 in the dorsal root ganglion …
are not well understood. Chemokine CCL2 has been implicated to play a vital role in the
neuroinflammation and central sensitization after spinal nerve ligation. Here we investigated
the expression and the role of CCL2 and its receptor CCR2 in LDH-induced pain.
Implantation of autologous nucleus pulposus induced persistent pain hypersensitivity,
associated with increased mRNA expression of CCL2 and CCR2 in the dorsal root ganglion …
