Monocyte chemoattractant protein-1: a key mediator in inflammatory processes
E Melgarejo, MÁ Medina, F Sánchez-Jiménez… - The international journal …, 2009 - Elsevier
E Melgarejo, MÁ Medina, F Sánchez-Jiménez, JL Urdiales
The international journal of biochemistry & cell biology, 2009•ElsevierMonocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and
macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to
coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple
inflammatory diseases, it is a potential target for the treatment of these disorders. In this
review, we will provide background information and summarize the MCP-1 structure and
signaling pathways. Its involvement in multiple diseases, such as tumour development …
macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to
coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple
inflammatory diseases, it is a potential target for the treatment of these disorders. In this
review, we will provide background information and summarize the MCP-1 structure and
signaling pathways. Its involvement in multiple diseases, such as tumour development …
Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple inflammatory diseases, it is a potential target for the treatment of these disorders. In this review, we will provide background information and summarize the MCP-1 structure and signaling pathways. Its involvement in multiple diseases, such as tumour development, atherogenesis and rare autoimmune diseases is also revised.
Elsevier
