MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism
S Aras, M Bai, I Lee, R Springett, M Hüttemann… - Mitochondrion, 2015 - Elsevier
Our understanding of stress-associated regulatory mechanisms for mitochondria remains
incomplete. We now report a new regulator of mitochondrial metabolism, the coiled-coil–
helix–coiled-coil–helix domain-containing protein 2 (CHCHD2) which, based on the
functionality described here, is renamed MNRR1 (Mitochondria Nuclear Retrograde
Regulator 1). It functions in a novel way by acting in two cellular compartments, mitochondria
and nucleus. In normally growing cells most MNRR1 is located in mitochondria; during …
incomplete. We now report a new regulator of mitochondrial metabolism, the coiled-coil–
helix–coiled-coil–helix domain-containing protein 2 (CHCHD2) which, based on the
functionality described here, is renamed MNRR1 (Mitochondria Nuclear Retrograde
Regulator 1). It functions in a novel way by acting in two cellular compartments, mitochondria
and nucleus. In normally growing cells most MNRR1 is located in mitochondria; during …
