[HTML][HTML] Transient contraction of mitochondria induces depolarization through the inner membrane dynamin OPA1 protein
H Lee, Y Yoon - Journal of Biological Chemistry, 2014 - ASBMB
Dynamin-related membrane remodeling proteins regulate mitochondrial morphology by
mediating fission and fusion. Although mitochondrial morphology is considered an important
factor in maintaining mitochondrial function, a direct mechanistic link between mitochondrial
morphology and function has not been defined. We report here a previously unrecognized
cellular process of transient contraction of the mitochondrial matrix. Importantly, we found
that this transient morphological contraction of mitochondria is accompanied by a reversible …
mediating fission and fusion. Although mitochondrial morphology is considered an important
factor in maintaining mitochondrial function, a direct mechanistic link between mitochondrial
morphology and function has not been defined. We report here a previously unrecognized
cellular process of transient contraction of the mitochondrial matrix. Importantly, we found
that this transient morphological contraction of mitochondria is accompanied by a reversible …
