Fatigue is a prominent symptom in many diseases and disorders and reduces quality of life
for many people. The lack of clear pathogenesis and failure of current interventions to
adequately treat fatigue in all patients leaves a need for new treatment options. Despite the
therapeutic need and importance of preclinical research in helping identify promising novel
treatments, few preclinical assays of fatigue are available. Moreover, the most common
preclinical assay used to assess fatigue-like behavior, voluntary wheel running, is not …