The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis
RJ Shei, JE Peabody, N Kaza, SM Rowe - Current opinion in pharmacology, 2018 - Elsevier
Download: Download high-res image (36KB) Download: Download full-size image Cystic
fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. CFTR dysfunction is characterized by
abnormal mucociliary transport due to a dehydrated airway surface liquid (ASL) and
hyperviscous mucus, among other pathologies of host defense. ASL depletion is caused by
the absence of CFTR mediated chloride secretion along with continued activity of the …
fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. CFTR dysfunction is characterized by
abnormal mucociliary transport due to a dehydrated airway surface liquid (ASL) and
hyperviscous mucus, among other pathologies of host defense. ASL depletion is caused by
the absence of CFTR mediated chloride secretion along with continued activity of the …