Plasma neutralization of the SARS-CoV-2 Omicron variant

F Schmidt, F Muecksch, Y Weisblum… - … England Journal of …, 2022 - Mass Medical Soc
F Schmidt, F Muecksch, Y Weisblum, J Da Silva, E Bednarski, A Cho, Z Wang, C Gaebler
New England Journal of Medicine, 2022Mass Medical Soc
Omicron Neutralization after the Third Vaccine Dose Neutralization assays of SARS-CoV-2
pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in
plasma drawn from 47 people over time showed much lower omicron neutralization than
Wuhan-hu-1 neutralization after two doses of an mRNA vaccine. However, samples from
persons vaccinated after recovery from Covid-19 and those who received a booster vaccine
had high levels of omicron neutralization.
Omicron Neutralization after the Third Vaccine Dose
Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over time showed much lower omicron neutralization than Wuhan-hu-1 neutralization after two doses of an mRNA vaccine. However, samples from persons vaccinated after recovery from Covid-19 and those who received a booster vaccine had high levels of omicron neutralization.
The New England Journal Of Medicine