High PIM1 expression is a biomarker of T-cell acute lymphoblastic leukemia with JAK/STAT activation or t(6;7)(p21;q34)/TRB@-PIM1 rearrangement
R La Starza, M Messina, V Gianfelici, V Pierini… - Leukemia, 2018 - nature.com
R La Starza, M Messina, V Gianfelici, V Pierini, C Matteucci, T Pierini, MZ Limongi, A Vitale…
Leukemia, 2018•nature.comPIM1, a member of the PIM family of short-lived serine/threonine kinases, is involved in the
control of cell growth, differentiation, and apoptosis and is highly conserved in mammals. It is
expressed in embryonic stem cells, hematopoietic, neuronal, smooth muscle, heart,
endothelial and epithelial cells through tight regulation at transcriptional and translational
levels [1]. Originally discovered as the site of murine T-cell lymphomas retroviral insertion,
transgenic mice provided the first evidence of PIM1 oncogenic potential since they …
control of cell growth, differentiation, and apoptosis and is highly conserved in mammals. It is
expressed in embryonic stem cells, hematopoietic, neuronal, smooth muscle, heart,
endothelial and epithelial cells through tight regulation at transcriptional and translational
levels [1]. Originally discovered as the site of murine T-cell lymphomas retroviral insertion,
transgenic mice provided the first evidence of PIM1 oncogenic potential since they …
PIM1, a member of the PIM family of short-lived serine/threonine kinases, is involved in the control of cell growth, differentiation, and apoptosis and is highly conserved in mammals. It is expressed in embryonic stem cells, hematopoietic, neuronal, smooth muscle, heart, endothelial and epithelial cells through tight regulation at transcriptional and translational levels [1].
Originally discovered as the site of murine T-cell lymphomas retroviral insertion, transgenic mice provided the first evidence of PIM1 oncogenic potential since they developed T-cell lymphomas after a short latency time [2]. In primary acute myeloid leukemia and B-cell acute lymphoblastic leukemia, PIM1 activation has been related to
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