Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Address correspondence to: Madhav Dhodapkar, Winship Cancer Institute, 1760 Haygood Drive, Atlanta, Georgia 30322, USA. Phone: 404.778.1900; Email: firstname.lastname@example.org.
First published February 25, 2019 - More info
Genetically engineered T cells have shown promising activity in the treatment of cancer. However, these cells are also potentially susceptible to immune-suppressive pathways in the tumor microenvironment that may limit their efficacy. In this issue of the JCI, Yamamoto et al. describe a new cellular engineering approach to prevent Fas-mediated inhibition of T cell function, which may be exploited to improve cellular therapy for cancer.
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